A woman raised in a motel in the countryside experiences twists and turns as she reunites with her first love in her hometown that she ran away from 12 years ago.

Boo Yong Joo was once a famous surgeon at the peak of his career at a major hospital. But he suddenly gives it all up one day to live in seclusion and work as a neighborhood doctor in a small town. He now goes by “Teacher Kim” and refers to himself as the “Romantic Doctor.” Meanwhile, Kang Dong Joo became a doctor to make something of himself after growing up poor, and he seeks out VIP patients to achieve the success that he desperately wants. Yoon Seo Jung is a passionate young surgeon who is haunted by a mistake from her past and tries to get over it. When Dong Joo and Seo Jung meet the quirky Teacher Kim, their lives and careers will never be the same again.

The story of a woman who has gone through several reincarnations over the course of 600 years and remembers all of her past lives and a man who has lived for over 600 years as a mythical creature that feeds off human blood and is cursed with immortality.

As a grisly virus rampages a city, a lone man stays locked inside his apartment, digitally cut off from seeking help and desperate to find a way out.

Although born in the same year, two childhood friends end up being 13 years apart because they have aged surprisingly at different places (worlds) for some strange reason. Now Eom Hyeon Soo is a 31-year-old woman but Sung Hae Sung is still a 18-year-old boy. Cha Won Yooung is a chef also interested in Eom Hyeon Soo.

In real life, Kwon Yoo is unemployed, but in the virtual game world he is the best leader. Kwon Yoo is then framed for a murder. With the help of hacker Yeo-Wool, he tries to uncover the truth behind the murder case.