When a blood sacrifice opens a portal to Hell, Ebee is returned to Earth where Lucy Furr, the new proprietor of her weed shop, has some sinister plans of her own.

After supervillain Shredder escapes custody, he joins forces with mad scientist Baxter Stockman and two dimwitted henchmen, Bebop and Rocksteady, to unleash a diabolical plan to take over the world. As the Turtles prepare to take on Shredder and his new crew, they find themselves facing an even greater evil with similar intentions: the notorious Krang.